Your liver is
like gold

Protect it with LEGALON FORTE 1

Clinically proven to support liver health and to provide supportive treatment in alcohol-induced liver disease. 15

Legalon Forte - packshot

The liver is a vital organ in the human body, responsible for over 500 functions and plays a key role in: 2

  • Breakdown of proteins, carbohydrates and fats
  • Removal of toxins from the body
  • Vitamin and mineral storage
  • Modulating the inflammatory response
  • Secretion of bile

What can cause liver damage?

The effects of chronic medication use, rich foods and alcohol can build-up over time which may affect your liver. 3, 4, 5, 6, 7

  • Chronic medication 5, 6, 7, 10
  • Toxins 2
  • Parasites and viruses (including hepatitis B and C) 4, 5
  • Unbalanced nutrition such as rich, fatty or processed foods 3
  • Herbal and dietary supplements 8, 9
  • Obesity 5
  • Metabolic disorders such as diabetes 3
  • Heavy alcohol use 4, 5
  • Smoking 4

Who is at risk? 3, 4, 5, 6

  • The elderly
  • Overweight & obese people
  • Chronic medication users

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Symptoms of liver damage are not specific and the damage is often overlooked.5,11

  • Fatigue
  • Nausea
  • Pruritus
    (itching)
  • Flatulence
    (excessive gas)
  • Jaundice
    (yellow skin discolouration)
  • General
    unwell feeling
  • Abdominal
    pain

These could be signs of liver damage.

LEGALON® FORTE: a unique, patented silymarin
preparation that looks after your liver.12, 13, 14, 15

Antioxidant - fights
against free
radicals that
damage cells13, 15

Anti-
inflammatory-
reduces swelling15

Legalon Forte - refesh icon - Assists in the regeneration of liver cells

Assists in the
regeneration
of liver cells15

Aids in the
treatment of
liver disease

Silymarin is the active ingredient in milk thistle, the most well-researched plant in the treatment of liver disease.1, 13

The health benefits found in 100 mg of silybin (silymarin compound) is equal to taking 1000 mg of milk thistle.13


LEGALON® FORTE is well tolerated with limited interactions and a low incidence of side effects. 14, 15, 16

Legalon Forte - man drinking capsule with glass of water

South Africa's
Only Registered
Silymarin
Preparation12

LEGALON®FORTE

Ingredients

LEGALON® FORTE – contains 140 mg Silymarin

How to take LEGALON®FORTE

Take 1 capsule 3 times daily.

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FAQ's

  • What is Legalon® Forte used for?

    The effects of chronic medication use, rich foods and alcohol can build-up over time which may affect your liver. 3, 4, 5, 6, 7 Legalon® Forte is clinically proven to support liver health and to provide supportive treatment in alcohol-induced liver disease.1

    Read more HERE

  • Is Legalon® Forte a supplement?

    Legalon® Forte may be used as a supplement. Clinical research has shown that it supports liver health and provides supportive treatment in alcohol-induced liver disease.15

    Read more HERE

  • What is the benefit of taking Legalon® Forte?

    LEGALON® Forte contains a unique, patented silymarin preparation that looks after your liver.12, 13, 14, 15

    • Antioxidant – fights against free radicals that damage cells
    • Anti-inflammatory – reduces swelling
    • Assists in the regeneration of liver cells
    • Aids in the treatment of liver disease

    Read more HERE

  • What is Silymarin?

    Silymarin is the active ingredient in milk thistle, the most well-researched plant in the treatment of liver disease. 1, 13 The health benefits found in 100 mg of silymarin is equal to taking 1000 mg of milk thistle.13.

    Read more HERE

  • Can Legalon® Forte cure liver disease?

    LEGALON® Forte contains a unique, patented silymarin preparation, and is clinically proven to provide supportive treatment in alcohol-induced liver disease but is not a cure.12, 15

    Read more HERE

References

  1. 1. Abenavoli L, Capasso R, Milic N, Capasso F. Milk Thistle in Liver Diseases: Past, Present, Future. Phytother Res. 2010;24: 1423-1432
  2. 2. Mazzoleni G, Steimberg N. New Models for the In Vitro Study of Liver Toxicity: 3D Culture Systems and the Role of Bioreactors. Chapters, in: Michael G. Tyshenko (ed.), The Continuum of Health Risk Assessments, IntechOpen. Available from: https://www.intechopen.com/books/the-continuum-of-health-risk-assessments/new-models-for-the-in-vitro-study-of-liver-toxicity-3d-culture-systems-and-the-role-of-bioreactors [Access 08 August 2021]
  3. 3. Yasutake K, Kohjima M, Kotoh K, Nakashima M, Nakamuta M, Enjoji M. Dietary habits and behaviors associated with nonalcoholic fatty liver disease. World J Gastroenterol. 2014;20(7): =1756-1767.
  4. 4. Wiegand J, Berg T. The Etiology, Diagnosis and Prevention of Liver Cirrhosis - Part 1 of a series on Liver Cirrhosis. Dtsch Arztebl Int. 2013;110(6):85-91
  5. 5. Mayo Clinic Staff. Liver Disease. Available from: https://www.mayoclinic.org/diseases-conditions/liver-problems/symptoms-causes/syc-20374502 [Accessed 5 November 2020].
  6. 6. Pérez-Jover V, Mira JJ, Carratala-Munuera C, Gil-Guillen VF, Basora J, López-Pineda A, et al. Inappropriate Use of Medication by Elderly, Polymedicated, or Multipathological Patients with Chronic Diseases. Int J Environ Res Public Health. 2018;15: 310. Available from: http://dx.doi.org/10.3390/ijerph15020310
  7. 7. Tholey D. Liver Injury Caused by Drugs. Merck Manual Consumer Version. Last reviewed April 2021. Available from: https://www.merckmanuals.com/home/liver-and-gallbladder-disorders/drugs-and-the-liver/liver-injury-caused-by-drugs. [Access 08 August 2021]
  8. 8. Navarro VJ, Khan I, Björnsson E, Seeff LB, Serrano J, Hoofnagle JH. Liver injury from herbal and dietary supplements. Hepatology. 2017;65(1):363-373
  9. 9. de Boer YS, Sherker AH. Herbal and Dietary Supplement-Induced Liver Injury. Clin Liver Dis. 2017;21(1):135-149
  10. 10. Sriuttha P, Sirichanchuen B, Permsuwan U. Hepatotoxicity of Nonsteroidal Anti-Inflammatory Drugs: A Systematic Review of Randomized Controlled Trials. Int J Hepatol. 2018 Jan 15;2018:5253623. doi: 10.1155/2018/5253623
  11. 11. Tholey D. Overview of Liver Disease. Merck Manual Consumer Version. Last reviewed February 2021. Available from: https://www.merckmanuals.com/home/liver-and-gallbladder-disorders/manifestations-of-liver-disease/overview-of-liver-disease?query=Liver%20Disease# [Accessed 08 August 2021]
  12. 12. Data on File. IMS/IQVIA Data MAT. July 2021
  13. 13. Liver Medic. Silybin vs Milk Thistle: Far Superior Bioavailability for Liver Disorders. 11 April 2017. Available from: https://www.livermedic.com/silybin-vs-milk-thistle-%E2%80%8Bfar-superior-bioavailability-for-liver-disorders/ [Accessed 08 August 2021].
  14. 14. Gillessen A, Schmidt HH. Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review. Adv Ther. 2020;37:1279-1301
  15. 15. Abenavoli L, Izzo AA, Milíc N, Cicala C, Santini A, Capasso R. Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases. Phytotherapy Research. 2018;32:2202-2213.
  16. 16. US Food and Drug Administration. Drug Interactions: What You Should Know. Available from: https://www.fda.gov/drugs/resources-you-drugs/drug-interactions-what-you-should-know [Accessed 4]
  17.  S0  LEGALON® FORTE (Capsules). Reg. No. 4.5/7.4/1132. Each tablet contains 140 mg silymarin. For full prescribing information, refer to the Professional Information approved by the Regulatory Authority. Marketed by: Mylan (Pty) Ltd. for Xixia Pharmaceuticals (Pty) Ltd. Reg No:1991/003162/07. 4 Brewery Street, Isando, Kempton Park, 1600. Tel: (011) 451 1300 Fax: (011) 451 1400 www.mylansa.co.za M4052 Exp: 11/2023

The purpose of this site is primarily to provide information and support.
Information and advice provided on this site is intended as support for liver damage sufferers and based on evidence available.
This site is not intended to endorse specific products as well as not to replace medical advice and medical diagnosis.

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