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References

  1. 1. Schellack N, Masuku P, Mogale K, Mokwele N, Skosana P. Hands on management of muscle pain and injuries. S Afr Pharm J 2018;85(6):27-36.
  2. 2. Hunter AM, Grigson C, Wade A. Influence of Topically Applied Menthol Cooling Gel on Soft Tissue Thermodynamics and Arterial and Cutaneous Blood Flow At Rest. Int J Sports Phys Ther. 2018;13(3):483-492.
  3. 3. Van den Bekerom MPJ, Stuijs PAA, Blankevoort L, Welling L, van Dijk N, Kerkhoffs GMMJ. What Is the Evidence for Rest, Ice, Compression, and Elevation Therapy in the Treatment of Ankle Sprains in Adults? J Athletic Training 2012;47(4):435-443
  4. 4. Gallelli L. Escin: a review of its anti-edematous, anti-inflammatory, and venotonic properties. Drug Des Devel Ther. 2019;13:3425-3437
  5. 5. Wetzel D, Menke W, Dieter R, Smasal V, Giannetti B, Bulitta M. Escin/diethylammonium salicylate/heparin combination gels for the topical treatment of acute impact injuries: a randomised, double blind, placebo controlled, multicentre study. Br J Sports Med. 2002; 36(3):183-188
  6. 6. Bonnekoh A, Rost R, Völker K, Giannetti BM, Bulitta M, Ley F. Double-blind, controlled clinical trial comparing an aescin combination gel with diclofenac diethlamine salt gel for efficacy and tolerability in volunteers with injection-induced haematoma. Deutsche Zeitschrift für Sportmedizin 1992;43(3):1-11.
  7. 7. Kotaka T, Kimura S, Kashiwayanagi M, Iwamoto J. Camphor induces cold and warm sensations with increases in skin and muscle blood flow in human. Biol Pharm Bull. 2014;37(12):1913-1918
  8. 8. Stevinson C, Devaraj VS, Fountain-Barber A, Hawkins S, Ernst E. Homeopathic arnica for prevention of pain and bruising: randomized placebo-controlled trial in hand surgery. J R Soc Med. 2003;96(2):60-65
  9. 9. European Medicines Agency. Committee on Herbal Medicinal Products (HMPC). Assessment report on Aesculus hippocastanum L., semen. Final – Revision 1. EMA/HMPC/638244/2018. 15 January 2020. Available from https://www.ema.europa.eu/en/documents/herbal-report/assessment-report-aesculus-hippocastanum-l-semen-final-revision-1_en.pdf [Accessed 22 November 2021]

  10. 10. European Medicines Agency. Horse-chestnut seed. EMA/60766/2020. 4 March 2020. Available from https://www.ema.europa.eu/en/medicines/herbal/hippocastani-semen [Accessed 22 November 2021]

  11.  S1  REPARIL® GEL Reg. No.: G/13.9/2367. Each 100 g contains Aescin 1,0 g and Diethylamine Salicylate 5,0 g.
  12. REPARIL® ICE-WRAP Contains Ethanol, Menthol, Arnica.
  13. REPARIL® ICE-SPRAY Contains Butane, pentane, isobutane, propane, isopropyl alcohol, menthol, camphor. For full prescribing information, |refer to the Professional Information approved by the Regulatory Authority.
  14. Marketed by Mylan (Pty) Ltd for Xixia Pharmaceuticals (Pty) Ltd. Reg No:1991/003162/07. 4 Brewery Street, Isando, Kempton Park, 1600. Tel: (011) 451 1300 Fax: (011) 451 1400 www.mylansa.co.za M4030 Exp: 11/2023

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